Description
An ATR inhibitor; inhibits proliferation in a panel of human tumor cell lines (mean IC50 = 78 nM); halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models; exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases